abstract：:In this review we discuss mucus, the viscoelastic secretion from goblet or mucous producing cells that lines the epithelial surfaces of all organs exposed to the external world. Mucus is a complex aqueous fluid that owes its viscoelastic, lubricating and hydration properties to the glycoprotein mucin combined with ele...

journal_title：Advanced drug delivery reviews

authors： Bansil R,Turner BS

更新日期：2018-01-15 00:00:00

abstract：:Nanomedicine, which is an application of nanotechnologies in healthcare is developed to improve the treatments and lives of patients suffering from a range of disorders and to increase the successes of drug candidates. Within the nanotechnology universe, the remarkable unique and tunable properties of dendrimers have ...

journal_title：Advanced drug delivery reviews

authors： Mignani S,Rodrigues J,Tomas H,Roy R,Shi X,Majoral JP

更新日期：2018-01-01 00:00:00

abstract：:Clinical trials are crucial to determining the human safety and efficacy of new therapeutic innovations. Extraordinary amounts of human experiential data are generated over the course of any clinical trial, however, much of these data is never made publicly accessible. Improved, reliable data sharing is essential to i...

journal_title：Advanced drug delivery reviews

authors： Fortunato A,Grainger DW,Abou-El-Enein M

更新日期：2018-01-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have been developed for a number of indications due to their regenerative and anti-inflammatory phenotypes and their utility is enhanced by the fact that allogeneic transplant is feasible with this cell type. Animal studies and early human cases indicate that this has the potential to be ...

journal_title：Advanced drug delivery reviews

authors： Rodgers K,Jadhav SS

更新日期：2018-01-01 00:00:00

abstract：:According to the latest report from the World Health Organization, an estimated 265,000 deaths still occur every year as a direct result of burn injuries. A widespread range of these deaths induced by burn wound happens in low- and middle-income countries, where survivors face a lifetime of morbidity. Most of the deat...

journal_title：Advanced drug delivery reviews

authors： Mofazzal Jahromi MA,Sahandi Zangabad P,Moosavi Basri SM,Sahandi Zangabad K,Ghamarypour A,Aref AR,Karimi M,Hamblin MR

更新日期：2018-01-01 00:00:00

abstract：:The encouraging pace of discovery and development in the field of regenerative medicine holds tremendous potential for bringing therapies to the clinic that may offer meaningful benefit to patients, particularly in diseases with no or suboptimal therapeutic options. Academic researchers will continue to play a critica...

journal_title：Advanced drug delivery reviews

authors： Nagpal A,Juttner C,Hamilton-Bruce MA,Rolan P,Koblar SA

更新日期：2017-12-01 00:00:00

abstract：:Fibrosis plays an important role in many different pathologies. It results from tissue injury, chronic inflammation, autoimmune reactions and genetic alterations, and it is characterized by the excessive deposition of extracellular matrix components. Biopsies are routinely employed for fibrosis diagnosis, but they suf...

journal_title：Advanced drug delivery reviews

authors： Baues M,Dasgupta A,Ehling J,Prakash J,Boor P,Tacke F,Kiessling F,Lammers T

更新日期：2017-11-01 00:00:00

abstract：:Adult neural stem and progenitor cells (NSPCs) offer a unique opportunity for neural regeneration and niche modification in physiopathological conditions, harnessing the capability to modify from neuronal circuits to glial scar. Findings exposing the vast plasticity and potential of NSPCs have accumulated over the pas...

journal_title：Advanced drug delivery reviews

authors： Encinas JM,Fitzsimons CP

更新日期：2017-10-01 00:00:00

abstract：:In the past 15years, despite that regenerative medicine has shown great potential for cardiovascular diseases, the outcome and safety of stem cell transplantation has shown controversial results in the published literature. Medical imaging might be useful for monitoring and quantifying transplanted cells within the he...

journal_title：Advanced drug delivery reviews

authors： Li X,Hacker M

更新日期：2017-10-01 00:00:00

abstract：:Angiogenesis is naturally balanced by many pro- and anti-angiogenic factors while an imbalance of these factors leads to aberrant angiogenesis, which is closely associated with many diseases. Gene therapy has become a promising strategy for the treatment of such a disordered state through the introduction of exogenous...

journal_title：Advanced drug delivery reviews

authors： Kim J,Mirando AC,Popel AS,Green JJ

更新日期：2017-09-15 00:00:00

abstract：:The once nascent field of immunoengineering has recently blossomed to include approaches to deliver and present biomolecules to program diverse populations of lymphocytes to fight disease. Building upon improved understanding of the molecular and physical mechanics of lymphocyte activation, varied strategies for engin...

journal_title：Advanced drug delivery reviews

authors： Ben-Akiva E,Meyer RA,Wilson DR,Green JJ

更新日期：2017-05-15 00:00:00

abstract：:Type 1 diabetes is an autoimmune disease marked by the destruction of insulin-producing beta cells in the pancreatic islets. Strategies to delay onset or prevent the autoimmune recognition of beta cell antigens or T cell-mediated killing of beta cells have mainly focused on systemic immunomodulation and antigen-specif...

journal_title：Advanced drug delivery reviews

authors： Baekkeskov S,Hubbell JA,Phelps EA

更新日期：2017-05-15 00:00:00

abstract：:Immunotherapy has been widely explored for applications to both augment and suppress intrinsic host immunity. Clinical achievements have seen a number of immunotherapeutic drugs displace established strategies like chemotherapy in treating immune-associated diseases. However, single drug approaches modulating an indiv...

journal_title：Advanced drug delivery reviews

authors： Stewart JM,Keselowsky BG

更新日期：2017-05-15 00:00:00

abstract：:Endosomes and lysosomes play a critical role in various aspects of cell physiology such as nutrient sensing, receptor recycling, protein/lipid catabolism, and cell death. In drug delivery, endosomal release of therapeutic payloads from nanocarriers is also important in achieving efficient delivery of drugs to reach th...

journal_title：Advanced drug delivery reviews

authors： Wang C,Zhao T,Li Y,Huang G,White MA,Gao J

更新日期：2017-04-01 00:00:00

abstract：:Blood contact with biomaterials triggers activation of multiple reactive mechanisms that can impair the performance of implantable medical devices and potentially cause serious adverse clinical events. This includes thrombosis and thromboembolic complications due to activation of platelets and the coagulation cascade,...

journal_title：Advanced drug delivery reviews

authors： Biran R,Pond D

更新日期：2017-03-01 00:00:00

abstract：:In principle, proton therapy offers a substantial clinical advantage over conventional photon therapy. This is because of the unique depth-dose characteristics of protons, which can be exploited to achieve significant reductions in normal tissue doses proximal and distal to the target volume. These may, in turn, allow...

journal_title：Advanced drug delivery reviews

authors： Mohan R,Grosshans D

更新日期：2017-01-15 00:00:00

abstract：:Sensorineural hearing loss (SNHL) is one of the most common diseases, accounting for about 90% of all hearing loss. Leading causes of SNHL include advanced age, ototoxic medications, noise exposure, inherited and autoimmune disorders. Most of SNHL is irreversible and managed with hearing aids or cochlear implants. Alt...

journal_title：Advanced drug delivery reviews

authors： Li L,Chao T,Brant J,O'Malley B Jr,Tsourkas A,Li D

更新日期：2017-01-01 00:00:00

abstract：:Successfully translating anti-cancer nanomedicines from pre-clinical proof of concept to demonstration of therapeutic value in the clinic is challenging. Having made significant advances with drug delivery technologies, we must learn from other areas of oncology drug development, where patient stratification and targe...

journal_title：Advanced drug delivery reviews

authors： Hare JI,Lammers T,Ashford MB,Puri S,Storm G,Barry ST

更新日期：2017-01-01 00:00:00

abstract：:Poly(lactic acid) (PLA) is a synthetic polyester that has shown extensive utility in tissue engineering. Synthesized either by ring opening polymerization or polycondensation, PLA hydrolytically degrades into lactic acid, a metabolic byproduct, making it suitable for medical applications. Specifically, PLA nanofibers ...

journal_title：Advanced drug delivery reviews

authors： Santoro M,Shah SR,Walker JL,Mikos AG

更新日期：2016-12-15 00:00:00

abstract：:Poly(lactic acid) (PLA), so far, is the most extensively researched and utilized biodegradable aliphatic polyester in human history. Due to its merits, PLA is a leading biomaterial for numerous applications in medicine as well as in industry replacing conventional petrochemical-based polymers. The main purpose of this...

journal_title：Advanced drug delivery reviews

authors： Farah S,Anderson DG,Langer R

更新日期：2016-12-15 00:00:00

abstract：:Unraveling the mechanisms of nanoparticle transport across the intestinal barrier is essential for designing more efficient nanoparticles for oral administration. The physicochemical parameters of the nanoparticles (e.g., size, surface charge, chemical composition) dictate nanoparticle fate across the intestinal barri...

journal_title：Advanced drug delivery reviews

authors： Beloqui A,des Rieux A,Préat V

更新日期：2016-11-15 00:00:00

abstract：:Theranostic systems support diagnostic and therapeutic functions in a single integrated entity and enable precise spatiotemporal control of the generation of therapeutic molecules according to the individual patient's disease state, thereby maximizing the therapeutic outcome and minimizing side effects. These systems ...

journal_title：Advanced drug delivery reviews

authors： Kojima R,Aubel D,Fussenegger M

更新日期：2016-10-01 00:00:00

abstract：:Carbon-based functional nanomaterials have attracted immense scientific interest from many disciplines and, due to their extraordinary properties, have offered tremendous potential in a diverse range of applications. Among the different carbon nanomaterials, graphene is one of the newest and is considered the most imp...

journal_title：Advanced drug delivery reviews

authors： Zhang B,Wei P,Zhou Z,Wei T

更新日期：2016-10-01 00:00:00

abstract：:Current treatment of human immunodeficiency virus type-1 (HIV-1) infection involves a combination of antiretroviral drugs (ARVs) that target different stages of the HIV-1 life cycle. This strategy is commonly referred to as highly active antiretroviral therapy (HAART) or combined antiretroviral therapy (cART). Membran...

journal_title：Advanced drug delivery reviews

authors： Alam C,Whyte-Allman SK,Omeragic A,Bendayan R

更新日期：2016-08-01 00:00:00

abstract：:Lipid based formulations (LBF) provide well proven opportunities to enhance the oral absorption of drugs and drug candidates that sit close to, or beyond, the boundaries of Lipinski's 'rule-of-five' chemical space. Advantages in permeability, efflux and presystemic metabolism are evident; however, the primary benefit ...

journal_title：Advanced drug delivery reviews

authors： Feeney OM,Crum MF,McEvoy CL,Trevaskis NL,Williams HD,Pouton CW,Charman WN,Bergström CAS,Porter CJH

更新日期：2016-06-01 00:00:00

abstract：:Nano- and microfabrication techniques have been widely explored in the textile, polymer and biomedical arenas, although more recently these systems have attracted considerable interest as drug delivery vehicles with concomitant considerations of physical characterization, scalability, stability and drug release. In th...

journal_title：Advanced drug delivery reviews

authors： Qi S,Craig D

更新日期：2016-05-01 00:00:00

abstract：:Spray drying is a well-established manufacturing technique which can be used to formulate amorphous solid dispersions (ASDs) which is an effective strategy to deliver poorly water soluble drugs (PWSDs). However, the inherently complex nature of the spray drying process coupled with specific characteristics of ASDs mak...

journal_title：Advanced drug delivery reviews

authors： Singh A,Van den Mooter G

更新日期：2016-05-01 00:00:00

abstract：:Amorphisation of poorly water-soluble drugs is one approach that can be applied to improve their solubility and thus their bioavailability. Amorphisation is a process that usually requires deliberate external energy input. However, amorphisation can happen both unintentionally, as in process-induced amorphisation duri...

journal_title：Advanced drug delivery reviews

authors： Priemel PA,Grohganz H,Rades T

更新日期：2016-05-01 00:00:00

abstract：:For poorly water soluble drugs, the amorphous state provides an avenue to enhance oral bioavailability. The preparation method, in addition to sample history, can dictate the nature and the stability of the amorphous phase. Conventionally, X-ray powder diffractometry is of limited utility for characterization, but str...

journal_title：Advanced drug delivery reviews

authors： Thakral S,Terban MW,Thakral NK,Suryanarayanan R

更新日期：2016-05-01 00:00:00

abstract：:Heparin and heparan sulfates are closely related linear anionic polysaccharides, called glycosaminoglycans, which exhibit a number of important biological and pharmacological activities. These polysaccharides, having complex structures and polydispersity, are biosynthesized in the Golgi of animal cells. While heparan ...

journal_title：Advanced drug delivery reviews

authors： Fu L,Suflita M,Linhardt RJ

更新日期：2016-02-01 00:00:00

abstract：:The research of integrin-targeted anticancer agents has recorded important advancements in ingenious design of delivery systems, based either on the prodrug approach, or on nanoparticle carriers, but for now, none of these has reached a clinical stage of development. Past work in this area has been extensively reviewe...

journal_title：Advanced drug delivery reviews

authors： Arosio D,Casagrande C

更新日期：2016-02-01 00:00:00

abstract：:Recreating the beating heart in the laboratory continues to be a formidable bioengineering challenge. The fundamental feature of the heart is its pumping action, requiring considerable mechanical forces to compress a blood filled chamber with a defined in- and outlet. Ventricular output crucially depends on venous loa...

journal_title：Advanced drug delivery reviews

authors： Liaw NY,Zimmermann WH

更新日期：2016-01-15 00:00:00

abstract：:Synthetic micro/nanomotors are tiny devices than can be self-propelled or externally powered in the liquid phase by different types of energy source including but not limited to: catalytic, magnetic or acoustic. Showing a myriad of mechanical movements, building block materials, sizes, shapes and propulsion mechanisms...

journal_title：Advanced drug delivery reviews

authors： Chałupniak A,Morales-Narváez E,Merkoçi A

更新日期：2015-12-01 00:00:00

abstract：:This paper reviews key issues found to affect acceptability and preferences for vaginal products to prevent HIV infection or HIV and pregnancy. We focus on the interplay between the biological and physico-chemical aspects of formulation and the social and behavioral issues that may affect use. The need for an HIV prev...

journal_title：Advanced drug delivery reviews

authors： Woodsong C,Holt JD

更新日期：2015-09-15 00:00:00

abstract：:Despite intensive surgical excision, radiation therapy, and chemotherapy, the current life expectancy for patients diagnosed with glioblastoma multiforme is only 12 to 15months. One of the approaches being explored to increase chemotherapeutic efficacy is to locally deliver chemotherapeutics encapsulated within degrad...

journal_title：Advanced drug delivery reviews

authors： Floyd JA,Galperin A,Ratner BD

更新日期：2015-08-30 00:00:00

abstract：:The application of block copolymer micelles (BCMs) in oncology has benefitted from advances in polymer chemistry, drug formulation and delivery as well as in vitro and in vivo biological models. While great strides have been made in each of these individual areas, there remains some disappointment overall, citing, in ...

journal_title：Advanced drug delivery reviews

authors： Eetezadi S,Ekdawi SN,Allen C

更新日期：2015-08-30 00:00:00

abstract：:Tip-enhanced Raman scattering (TERS) has become a powerful tool for nanoscale structural analysis for several branches of organic, inorganic, and biological chemistry. This highly sensitive technique enables molecular characterization with a lateral resolution far beyond Abbe's diffraction limit and correlates structu...

journal_title：Advanced drug delivery reviews

authors： Sharma G,Deckert-Gaudig T,Deckert V

更新日期：2015-07-15 00:00:00

abstract：:miRNA-based technologies provide attractive tools for several liver tissue engineering approaches. Herein, we review the current state of miRNA applications in liver tissue engineering. Several miRNAs have been implicated in hepatic disease and proper hepatocyte function. However, the clinical translation of these fin...

journal_title：Advanced drug delivery reviews

authors： Raschzok N,Sallmon H,Pratschke J,Sauer IM

更新日期：2015-07-01 00:00:00

abstract：:Cytochrome P450 enzymes (CYPs) form one of the most important enzyme families involved in the metabolism of xenobiotics. CYPs comprise many isoforms, which catalyze a wide variety of reactions, and potentially, a large number of different metabolites can be formed. However, it is often hard to rationalize what metabol...

journal_title：Advanced drug delivery reviews

authors： Olsen L,Oostenbrink C,Jørgensen FS

更新日期：2015-06-23 00:00:00

abstract：:The use of in silico tools within the drug development process to predict a wide range of properties including absorption, distribution, metabolism, elimination and toxicity has become increasingly important due to changes in legislation and both ethical and economic drivers to reduce animal testing. Whilst in silico ...

journal_title：Advanced drug delivery reviews

authors： Hewitt M,Ellison CM,Cronin MT,Pastor M,Steger-Hartmann T,Munoz-Muriendas J,Pognan F,Madden JC

更新日期：2015-06-23 00:00:00